This chapter focuses on the social contexts and cultural meanings of Amphetamine Type Stimulant (ATS) use (e.g. amphetamine, methamphetamine, dexamphetamine, MDMA [ecstasy]). Understanding these social contexts and cultural meanings is important because they shape the ways in which ATS are understood and experienced. The effects of ATS, from experiences of intoxication to experiences of ‘dependence’, are not simply the product of pharmacology. Drugs and drug use are simultaneously the product of the interpretations and shared meanings constructed by the people who consume them and these interpretations and meanings are themselves the products of particular social, cultural, political, economic and historical contexts. Furthermore, these meanings are not fixed. Rather they are produced and reproduced in ongoing processes of social negotiation and contestation. Thus, ATS effects are produced through the interactions of pharmacology, subjectivity, micro-contexts (e.g. social relationships, symbolic meanings), and macro-contexts (i.e. the broader social, cultural, political, economic and historical contexts).