The N-ICE trial: A randomised controlled trial of the safety and efficacy of N-acetyl cysteine (NAC) as a pharmacotherapy for methamphetamine ('ice') dependence

• Chief Investigator: Rebecca McKetin, University of New South Wales
• Chief Investigator: Olivia Dean, Deakin University
• Chief Investigator: Dan Lubman, Monash University
• Chief Investigator: Peter Higgs, Burnet Institute
• Chief Investigator: Peter Kelly, University of Wollongong
• Chief Investigator: Alyna Turner, Deakin University
• Chief Investigator: Brendan Quinn, Burnet Institute
• Chief Investigator: Gregory Carter, University of Newcastle
• Co-investigator: Amanda Baker, University of Newcastle
• Co-investigator: Michael Berk, Deakin University
• Co-investigator: Barbara Sinclair, Wollongong Hospital
• Co-investigator: David Reid, Drug and Alcohol Services, Wollongong
• Co-investigator: Ruth Collins, Drug and Alcohol Clinical Services, Barwon Health
• Co-investigator: Wenbin Liang, Curtin University
• Project staff: Nina te Pas, Curtin University
• Project staff: Nicole Edwards, Curtin University

This project aligns with the following Sustainable Development Goals and Targets:

Arunogiri, S., McKetin, R., Verdejo-Garcia, A. and Lubman, D. (2020). The methamphetamine-associated psychosis spectrum: A clinically focused review. International Journal of Mental Health and Addiction, 28, (1), pp. 56-65. doi:10.1007/s11469-018-9934-4 [RJ1425] View web page

McKetin, R., Dean, O., Turner, A., Kelly, P., Quinn, B., Lubman, D., Dietze, P., Carter, G., Higgs, P., Baker, A., Sinclair, B., Reid, D., Manning, V., te Pas, N., Liang, W., Thomas, T., Bathish, R., Kent, M., Raftery, D., Arunogiri, S. and Berk, M. (2019). A study protocol for the N-ICE trial: A randomised double-blind placebo-controlled study of the safety and efficacy of N-acetyl-cysteine (NAC) as a pharmacotherapy for methamphetamine (ice) dependence. Trials, 20, (1). doi:10.1186/s13063-019-3450-0 [RJ1485] View web page

McKetin, R., Dean, O., Baker, A., Carter, G., Turner, A., Kelly, P. and Berk, M. (2017). A potential role for N-acetylcysteine in the management of methamphetamine dependence. Drug and Alcohol Review, 36, (2), pp. 153–159. doi:10.1111/dar.12414 [RJ1236] View web page